Call for Papers:Vol.11 Issue.3

Submission
Last date		 28-Jun-2025
Acceptance Status In One Day
Paper Publish In Two Days
Submit ManuScript

News & Updates

Submit Article

Dear Authors, Article publish in our journal for Volume-11,Issue-3. For article submission on below link: Submit Manuscript


Join As Board

Dear Reviewer, You can join our Reviewer team without given any charges in our journal. Submit Details on below link: Join As Board


Paper Publication Charges

IJARIIE APP
Download Android App

For Authors

Archives

IJARIIE Board

Downloads

Android App

Download IJARIIE APP

Authors

Title: :  THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER
PaperId: :  26725
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 3 2025
DUI:    16.0415/IJARIIE-26725
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
PRADNYA MAHENDRA BHOPLEVIDYABHARATI COLLEGE OF PHARMACY,SANT GADGE BABA AMRAVATI UNIVERSITY ,AMRAVATI
ANJALI M. WANKHADE VIDYABHARATI COLLEGE OF PHARMACY,SANT GADGE BABA AMRAVATI UNIVERSITY ,AMRAVATI
VIVEK V. PAITHANKARVIDYABHARATI COLLEGE OF PHARMACY,SANT GADGE BABA AMRAVATI UNIVERSITY ,AMRAVATI

Abstract

M.pharm in Pharmacology
PTSD, Evolvulus alsinoides, Single Prolonged Stress, Herbal medicine, Anxiety, Depression, Neuroprotection, Fear extinction
Post-Traumatic Stress Disorder (PTSD) is a chronic psychiatric condition triggered by traumatic experiences, presenting with symptoms such as intrusive thoughts, hyperarousal, avoidance, and cognitive impairment. Current treatments are often inadequate and associated with adverse effects. This study evaluates the therapeutic potential of the ethanolic extract of Evolvulus alsinoides (EEEA) in a validated Single Prolonged Stress (SPS) mouse model of PTSD. Swiss albino mice were subjected to SPS involving restraint, forced swim, and ether anesthesia, followed by a 7-day incubation period. Animals were then treated orally for 14 days with vehicle, fluoxetine (10 mg/kg), or EEEA at doses of 100, 200, and 400 mg/kg. Behavioral analyses included the Elevated Plus Maze, Forced Swim Test, Sucrose Preference Test, Social Interaction Test, Y-Maze, Marble Burying Test, and Fear Conditioning with Extinction. EEEA, particularly at 400 mg/kg, significantly improved anxiety-like, depressive, and cognitive behaviors by increasing open arm entries (6.64 ± 0.03), reducing immobility (60.77 ± 0.78 s), enhancing sucrose intake (2.72 ± 0.04 mL), social interaction (30.94 ± 0.02 s), spontaneous alternation, and reducing marble burying (8.51 ± 0.13). Phytochemical analysis confirmed the presence of flavonoids, alkaloids, tannins, glycosides, and phenolics. These findings suggest that Evolvulus alsinoides exerts significant anxiolytic, antidepressant, and cognitive-enhancing effects in PTSD, likely through neuromodulatory and neuroprotective mechanisms, and may serve as a promising herbal therapeutic

Citations

Copy and paste a formatted citation or use one of the links to import into a bibliography manager and reference.

IJARIIE PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. "THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 3 2025 Page 2185-2193
MLA PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. "THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER." International Journal Of Advance Research And Innovative Ideas In Education 11.3(2025) : 2185-2193.
APA PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , & VIVEK V. PAITHANKAR. (2025). THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER. International Journal Of Advance Research And Innovative Ideas In Education, 11(3), 2185-2193.
Chicago PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. "THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 3 (2025) : 2185-2193.
Oxford PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. 'THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 3, 2025, p. 2185-2193. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/THERAPEUTIC_POTENTIAL_OF_EVOLVULUS_ALSINOIDES_EXTRACT_IN_SINGLE_PROLONGED_STRESS_INDUCED_ANIMAL_MODEL_OF_POST_TRAUMATIC_STRESS_DISORDER_ijariie26725.pdf (Accessed : ).
Harvard PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. (2025) 'THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER', International Journal Of Advance Research And Innovative Ideas In Education, 11(3), pp. 2185-2193IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/THERAPEUTIC_POTENTIAL_OF_EVOLVULUS_ALSINOIDES_EXTRACT_IN_SINGLE_PROLONGED_STRESS_INDUCED_ANIMAL_MODEL_OF_POST_TRAUMATIC_STRESS_DISORDER_ijariie26725.pdf (Accessed : )
IEEE PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR, "THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 3, pp. 2185-2193, May-Jun 2025. [Online]. Available: https://ijariie.com/AdminUploadPdf/THERAPEUTIC_POTENTIAL_OF_EVOLVULUS_ALSINOIDES_EXTRACT_IN_SINGLE_PROLONGED_STRESS_INDUCED_ANIMAL_MODEL_OF_POST_TRAUMATIC_STRESS_DISORDER_ijariie26725.pdf [Accessed : ].
Turabian PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. "THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 3 ().
Vancouver PRADNYA MAHENDRA BHOPLE, ANJALI M. WANKHADE , and VIVEK V. PAITHANKAR. THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDER. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(3) : 2185-2193. Available from: https://ijariie.com/AdminUploadPdf/THERAPEUTIC_POTENTIAL_OF_EVOLVULUS_ALSINOIDES_EXTRACT_IN_SINGLE_PROLONGED_STRESS_INDUCED_ANIMAL_MODEL_OF_POST_TRAUMATIC_STRESS_DISORDER_ijariie26725.pdf
BibTex EndNote RefMan RefWorks

Number Of Downloads



Save in Google Drive

Similar-Paper

TitleArea of ResearchAuther NameAction
ANTIHYPERLIPIDEMIC ACTIVITITY OF MEDICINAL PLANT IN HIGH FAT DIET INDUCED HYPERLIPEMIA IN EXPERIMENTAL ANIMALM.pharm in PharmacologyBhakti Nagare Download
PHYTOCHEMICAL SCREENING, FORMULATION AND EVALUATION OF ANTIBACTERIAL CREAM CONTAINING EPIPHYLLUM OXYPETALUM EXTRACTB-PharmacyMansi Dadasaheb Karande Download
THERAPEUTIC POTENTIAL OF EVOLVULUS ALSINOIDES EXTRACT IN SINGLE PROLONGED STRESS INDUCED ANIMAL MODEL OF POST TRAUMATIC STRESS DISORDERM.pharm in PharmacologyPRADNYA MAHENDRA BHOPLE Download
EXPLORING CYNODON DACTYLON AS A NATURAL REMEDY FOR A GASTRIC DISORDER VIA SYRUP FORMULATIONPHARMACYADITI MHATRE Download
THE ROLE OF PIPER LONGUM IN OVARIAN-METABOLIC MODULATIONpharmacySONAL JAIN Download
Formulation And Evaluation of Herbal Oil In The Treatment of Rheumatoid ArthritisPharmacy Ms. Sakshi Narayan Manal Download
SEEDS: ANTI-OXIDANT POWERHOUSEPharmacy DIVYA BALNE Download
The Role of Pharmacogenomics in Personalized MedicinePharmaceutical Sudipta Maitra Download
Understanding Zoonotic Diseases: Mechanisms of Transmission, Global Impact, and Strategies for Prevention and ControlPharmacyTejaswini Shivaji Khot Download
PharmacogenomicsPharmacologyMr Vijay kalyan Bhosale Download
A Review on Post Traumatic Stress DisorderPharamaceuticalDr. D. Rama Brahma Reddy Download
A REVIEW ON PHARMACEUTICAL GELSpharmaceuticsDr. R. Rama Brahma Reddy Download
REVIEW ON CERVICAL CANCERPharmaceuticsDr. D. Rama Brahma Reddy Download
FOMULATION AND EVALUATION OF METFORMIN AND VILDAGLIPTIN BILAYER TABLETSM. PHARMJeetendra kushwaha Download
REVIEW ON A FORMULATION, EVALUATION PARAMETERS OF HERBAL PARAMETERS OF HERBAL TOOTH POWDER BY USING HERBAL DRUGSPharmacyPawar Sakshi.N Download
12