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Title: :  IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS
PaperId: :  27117
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 4 2025
DUI:    16.0415/IJARIIE-27117
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
INNOCENT CHIBUIKE ANTHONY Imo State University
Omeni-Pius Raymond Onyedikachukwu University of Agriculture and Environmental sciences Umuagwo

Abstract

Bio Chemistry
Crude Oil, Hazard, biological systems.
Crude oil exploration and production pose significant environmental and health risks, particularly in oil-producing regions like Ohaji Egbema, Imo State, Nigeria. This study aimed to assess the impact of crude oil contamination on selected biochemical parameters in Wistar albino rats, serving as experimental models. Twenty adult rats were divided into four groups: a control group (Group A) and three experimental groups (Groups B, C, and D) exposed to crude oil via contaminated feed, water, and air, respectively, for 21 days. Biochemical assays were performed to evaluate liver and kidney function, hematological parameters, serum antioxidant status, and pro-inflammatory cytokine levels. Results revealed that exposure to crude oil led to elevated levels of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), indicative of liver damage. Kidney function parameters, including urea and creatinine levels, were also significantly elevated in exposed groups. Moreover, hematological analysis demonstrated decreased hemoglobin levels, altered white blood cell counts, and reduced platelet counts in rats exposed to crude oil. Furthermore, exposure to crude oil resulted in decreased serum antioxidant levels, including glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase, indicating oxidative stress. In addition, pro-inflammatory cytokine levels, such as interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNF-α) were markedly elevated in exposed groups compared to the control. These findings underscore the adverse effects of crude oil pollution on biological systems and highlight the importance of environmental monitoring and public health interventions in mitigating the risks associated with crude oil contamination.

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IJARIIE INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . "IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 4 2025 Page 989-1003
MLA INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . "IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS." International Journal Of Advance Research And Innovative Ideas In Education 11.4(2025) : 989-1003.
APA INNOCENT CHIBUIKE ANTHONY , & Omeni-Pius Raymond Onyedikachukwu . (2025). IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS. International Journal Of Advance Research And Innovative Ideas In Education, 11(4), 989-1003.
Chicago INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . "IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 4 (2025) : 989-1003.
Oxford INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . 'IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 4, 2025, p. 989-1003. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/IMPACT_OF_CRUDE_OIL_CONTAMINATION_ON_SELECTED_BIOCHEMICAL_PARAMETERS_IN_ALBINO_RATS_ijariie27117.pdf (Accessed : ).
Harvard INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . (2025) 'IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS', International Journal Of Advance Research And Innovative Ideas In Education, 11(4), pp. 989-1003IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/IMPACT_OF_CRUDE_OIL_CONTAMINATION_ON_SELECTED_BIOCHEMICAL_PARAMETERS_IN_ALBINO_RATS_ijariie27117.pdf (Accessed : )
IEEE INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu , "IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 4, pp. 989-1003, Jul-Aug 2025. [Online]. Available: https://ijariie.com/AdminUploadPdf/IMPACT_OF_CRUDE_OIL_CONTAMINATION_ON_SELECTED_BIOCHEMICAL_PARAMETERS_IN_ALBINO_RATS_ijariie27117.pdf [Accessed : ].
Turabian INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . "IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 4 ().
Vancouver INNOCENT CHIBUIKE ANTHONY , and Omeni-Pius Raymond Onyedikachukwu . IMPACT OF CRUDE OIL CONTAMINATION ON SELECTED BIOCHEMICAL PARAMETERS IN ALBINO RATS. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(4) : 989-1003. Available from: https://ijariie.com/AdminUploadPdf/IMPACT_OF_CRUDE_OIL_CONTAMINATION_ON_SELECTED_BIOCHEMICAL_PARAMETERS_IN_ALBINO_RATS_ijariie27117.pdf
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