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Title: :  REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM
PaperId: :  27362
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 4 2025
DUI:    16.0415/IJARIIE-27362
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Miss.Ashwini M. KhiratkarDepartment of Pharmaceutics Hi-Tech College of Pharmacy, Chandrapur
Dr.Pankaj M.PimpalshendePrincipal,Department of Pharmaceutics Hi-Tech College of Pharmacy, Chandrapur

Abstract

Pharmacy
: Chronotherapy, Pulsatile Drug Delivery Systems, Chronomodulated drug delivery system
Oral controlled drug delivery systems offer several advantages over conventional immediate release dosage forms by maintaining therapeutic drug concentrations for prolonged periods. However, many chronic diseases such as asthma, arthritis, cardiovascular disorders, and diabetes exhibit circadian rhythms, demanding time-scheduled drug release for optimal therapeutic outcomes. Chronomodulated drug delivery systems (CHDDS) are designed to synchronize drug availability with biological rhythms, thereby maximizing therapeutic efficacy while minimizing adverse effects. Pulsatile drug delivery systems (PDDS), a promising approach within CHDDS, release drugs in a rapid and burst manner following a programmable lag time. Various single-unit systems (e.g., Pulsincap®, Port® system, Time Clock® system) and multiple-unit systems employing rupturable or erodible coatings have been developed to achieve precise lag-controlled release. These systems are particularly beneficial for drugs with extensive first-pass metabolism, short or long half-lives, or those requiring site-specific release. Despite challenges such as complex manufacturing and higher costs, PDDS provide significant clinical benefits including improved bioavailability, reduced side effects, better patient compliance, and effective chronotherapy. Thus, pulsatile drug delivery represents a vital advancement for managing diseases influenced by circadian variations.

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IJARIIE Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. "REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 4 2025 Page 3676-3683
MLA Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. "REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM." International Journal Of Advance Research And Innovative Ideas In Education 11.4(2025) : 3676-3683.
APA Miss.Ashwini M. Khiratkar, & Dr.Pankaj M.Pimpalshende. (2025). REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM. International Journal Of Advance Research And Innovative Ideas In Education, 11(4), 3676-3683.
Chicago Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. "REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 4 (2025) : 3676-3683.
Oxford Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. 'REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 4, 2025, p. 3676-3683. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/REVIEW_ON__PULSATILE_DRUG_DELIVERY_SYSTEM_ijariie27362.pdf (Accessed : ).
Harvard Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. (2025) 'REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM', International Journal Of Advance Research And Innovative Ideas In Education, 11(4), pp. 3676-3683IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/REVIEW_ON__PULSATILE_DRUG_DELIVERY_SYSTEM_ijariie27362.pdf (Accessed : )
IEEE Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende, "REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 4, pp. 3676-3683, Jul-Aug 2025. [Online]. Available: https://ijariie.com/AdminUploadPdf/REVIEW_ON__PULSATILE_DRUG_DELIVERY_SYSTEM_ijariie27362.pdf [Accessed : ].
Turabian Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. "REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 4 ().
Vancouver Miss.Ashwini M. Khiratkar, and Dr.Pankaj M.Pimpalshende. REVIEW ON: PULSATILE DRUG DELIVERY SYSTEM. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(4) : 3676-3683. Available from: https://ijariie.com/AdminUploadPdf/REVIEW_ON__PULSATILE_DRUG_DELIVERY_SYSTEM_ijariie27362.pdf
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