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Title: :  To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review
PaperId: :  27863
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 6 2025
DUI:    16.0415/IJARIIE-27863
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mujeeb-Ur-RehmanDepartment of Pediatric And Congenital Cardiac Surgery First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China
Najeeb UllahDepartment of Endocrinology First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China
Mubashir HasanDepartment of Radiology First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China
Corresponding Author *Dr. Ma ChuangDept. of Orthopedics and Micro vascular Surgery, First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China

Abstract

Medicine/Surgery
 Multiple driver gene mutations (MDGMs),Non-small cell lung cancer (NSCLC),Mutation,Adenocarcinoma.
Non-small cell lung cancer (NSCLC) is genetically heterogeneous, with key genetic mutations guiding targeted therapy. While single driver mutations (e.g., EGFR, ALK) are well-characterized,the frequency and clinical impact of multiple driver gene mutations (MDGMs) is defined as concurrent pathogenic variants in two or more actionable driver genes which remain understudied till now. This comprehensive review synthesizes 68 studies (2015–2024) covering in total of  42,389 NSCLC patients to quantify MDGM incidence,characterize mutation co-occurrence patterns,and evaluate associations with clinicopathological features (histology, smoking status, stage) and treatment outcomes.MDGMs were detected in 8.3–15.7% of NSCLC cases,with the highest incidence in adenocarcinoma (10.1–18.4%) and lowest in squamous cell carcinoma (3.2–7.6%). The most common co-occurring mutation pairs were EGFR + KRAS (2.1–3.8%),EGFR + MET (1.7–2.9%), and ALK + ROS1 (0.8–1.5%). MDGM incidence was higher in never-smokers (12.4–16.8%) vs smokers (6.2–9.5%)and advanced-stage (III–IV) vs early-stage (I–II) disease (11.3–17.2% vs. 5.1–8.9%). Therapeutic response to single-agent targeted therapy was poorer in MDGM patients (progression-free survival [PFS]: 4.2–6.8 months) vs single driver mutation patients (PFS: 9.5–14.3 months),which reflects the need for mixed targeted strategies.This review underscores MDGMs as a distinct subgroup in NSCLC with unique clinical characteristics, which covers the importance of comprehensive genomic profiling to guide personalized therapy.

Citations

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IJARIIE Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. "To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 6 2025 Page 1833-1842
MLA Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. "To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review." International Journal Of Advance Research And Innovative Ideas In Education 11.6(2025) : 1833-1842.
APA Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, & Corresponding Author *Dr. Ma Chuang. (2025). To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review. International Journal Of Advance Research And Innovative Ideas In Education, 11(6), 1833-1842.
Chicago Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. "To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 6 (2025) : 1833-1842.
Oxford Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. 'To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 6, 2025, p. 1833-1842. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/To_identify_the_Multiple_Driver_Gene_Mutations_in_Non_Small_Cell_Lung_Cancer__NSCLC___A_Comprehensive_Review_ijariie27863.pdf (Accessed : ).
Harvard Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. (2025) 'To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review', International Journal Of Advance Research And Innovative Ideas In Education, 11(6), pp. 1833-1842IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/To_identify_the_Multiple_Driver_Gene_Mutations_in_Non_Small_Cell_Lung_Cancer__NSCLC___A_Comprehensive_Review_ijariie27863.pdf (Accessed : )
IEEE Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang, "To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 6, pp. 1833-1842, Nov-Dec 2025. [Online]. Available: https://ijariie.com/AdminUploadPdf/To_identify_the_Multiple_Driver_Gene_Mutations_in_Non_Small_Cell_Lung_Cancer__NSCLC___A_Comprehensive_Review_ijariie27863.pdf [Accessed : ].
Turabian Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. "To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 6 ().
Vancouver Mujeeb-Ur-Rehman, Najeeb Ullah, Mubashir Hasan, and Corresponding Author *Dr. Ma Chuang. To identify the Multiple Driver Gene Mutations in Non-Small Cell Lung Cancer (NSCLC): A Comprehensive Review. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(6) : 1833-1842. Available from: https://ijariie.com/AdminUploadPdf/To_identify_the_Multiple_Driver_Gene_Mutations_in_Non_Small_Cell_Lung_Cancer__NSCLC___A_Comprehensive_Review_ijariie27863.pdf
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