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Title: :  DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM
PaperId: :  27966
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 1 2026
DUI:    16.0415/IJARIIE-27966
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr. M. Venkata RamanaSurabhi Dayakar Rao College of Pharmacy
kanchugantla DurgaSurabhi Dayakar Rao College of Pharmacy

Abstract

Pharmacy
Lesinurad and Allopurinol, RP-HPLC, Validation, Accuracy, Robustness.
A streamlined, repeatable, and effective high-performance liquid chromatographic technique was developed for the simultaneous confirmation of Lesinurad and Allopurinol in pure form and showcased mixed pharmaceutical dosage forms. An isocratic mode column with a symmetry (C18) (150mm x 4.6mm, 5µm) and a flexible buffer consisting of Methanol: Phosphate (pH-3.8) (28:72% v/v) was previously used. Radiation at 252 nm was measured at a flow rate of 1 ml/min. Both Lesinurad and Allopurinol exhibited aid times of 1.794 and 3.440 minutes, respectively, and linearity extends of 10-30 and 10-50 parts per million, respectively. Linearity, accuracy, precision, satisfactoryness, limitation of disclosure, and management of quantification are all qualities that have been praised for the methodology. The limits of detection (LOD) and limits of quantification (LOQ) for Lesinurad were found to be 0.86µg/ml and 2.58µg/ml, respectively, whereas for Allopurinol the values were 1.28µg/ml and 3.84µg/ml. It was found that the produced method was accurate, precise, and applicable to the simultaneous confirmation of Lesinurad and Allopurinol in tablets.

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IJARIIE Dr. M. Venkata Ramana, and kanchugantla Durga. "DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 1 2026 Page 317-321
MLA Dr. M. Venkata Ramana, and kanchugantla Durga. "DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education 12.1(2026) : 317-321.
APA Dr. M. Venkata Ramana, & kanchugantla Durga. (2026). DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM. International Journal Of Advance Research And Innovative Ideas In Education, 12(1), 317-321.
Chicago Dr. M. Venkata Ramana, and kanchugantla Durga. "DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 1 (2026) : 317-321.
Oxford Dr. M. Venkata Ramana, and kanchugantla Durga. 'DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, 2026, p. 317-321. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_NEW_ANALYTICAL_REVERSE_PHASE__HPLC_METHOD_FOR_THE_SIMULTANEOUS_DETERMINATION_OF_LESINURAD_AND_ALLOPURINOL_IN_PURE_FORM_AND_MARKETED_COMBINED_DOSAGE_FORM_ijariie27966.pdf (Accessed : ).
Harvard Dr. M. Venkata Ramana, and kanchugantla Durga. (2026) 'DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM', International Journal Of Advance Research And Innovative Ideas In Education, 12(1), pp. 317-321IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_NEW_ANALYTICAL_REVERSE_PHASE__HPLC_METHOD_FOR_THE_SIMULTANEOUS_DETERMINATION_OF_LESINURAD_AND_ALLOPURINOL_IN_PURE_FORM_AND_MARKETED_COMBINED_DOSAGE_FORM_ijariie27966.pdf (Accessed : )
IEEE Dr. M. Venkata Ramana, and kanchugantla Durga, "DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, pp. 317-321, Jan-Feb 2026. [Online]. Available: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_NEW_ANALYTICAL_REVERSE_PHASE__HPLC_METHOD_FOR_THE_SIMULTANEOUS_DETERMINATION_OF_LESINURAD_AND_ALLOPURINOL_IN_PURE_FORM_AND_MARKETED_COMBINED_DOSAGE_FORM_ijariie27966.pdf [Accessed : ].
Turabian Dr. M. Venkata Ramana, and kanchugantla Durga. "DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 1 ().
Vancouver Dr. M. Venkata Ramana, and kanchugantla Durga. DEVELOPMENT AND VALIDATION OF A NEW ANALYTICAL REVERSE PHASE- HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF LESINURAD AND ALLOPURINOL IN PURE FORM AND MARKETED COMBINED DOSAGE FORM. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : ]; 12(1) : 317-321. Available from: https://ijariie.com/AdminUploadPdf/DEVELOPMENT_AND_VALIDATION_OF_A_NEW_ANALYTICAL_REVERSE_PHASE__HPLC_METHOD_FOR_THE_SIMULTANEOUS_DETERMINATION_OF_LESINURAD_AND_ALLOPURINOL_IN_PURE_FORM_AND_MARKETED_COMBINED_DOSAGE_FORM_ijariie27966.pdf
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