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Title: :  Liver Disease in Pregnancy: A Comprehensive Clinical Analysis
PaperId: :  28025
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 1 2026
DUI:    16.0415/IJARIIE-28025
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Roshan ShahDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.
Prof. Wang Zhimei Department of Obstetrics and Gynecology, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.

Abstract

Medical (Gynecology)
HELLP syndrome: Intrahepatic Cholestasis of Pregnancy: Liver disease in pregnancy: Pre-eclampsia.
Introduction: Liver disease in pregnancy represents a spectrum of conditions that pose significant risks to both maternal and fetal health. For the cross-sectional study purpose, major pregnancy-related liver disorders- HELLP syndrome, Pre-eclampsia with hepatic involvement, Intrahepatic Cholestasis of Pregnancy (ICP), Acute Fatty Liver of Pregnancy (AFLP) and Hyperemesis Gravidarum (HG), patients from first affiliated hospital of Xinjiang Medical University, Xinjiang, China was taken. By comparing demographic characteristics, clinical presentation, laboratory parameters, management approaches, and maternal-fetal outcomes across these conditions, we aim to provide clinicians with enhanced understanding of their distinct pathophysiologies and optimal management strategies. Method: A cross-sectional study examined 80 pregnant women with liver disorders treated from November 2023 to November 2024. Demographic data, clinical presentation, laboratory parameters, management approaches, and maternal-fetal outcomes were taken from the day of diagnosis from outpatient and administration department till the delivery of the patient. Statistical analysis was performed. Reference were taken from the PUBMED. Result: HELLP syndrome (n=12) presented with hemolysis, severe thrombocytopenia and hepatic enzyme elevation, resulting in 33.33% perinatal mortality; Pre-eclampsia (n=23) demonstrated significant proteinuria with preserved liver function, showing 8.7% perinatal mortality; ICP (n=45) exhibited pruritus with bile acid elevation, resulting in 13.33% perinatal mortality; AFLP (n=0) and HG (n=0) overall perinatal mortality15% (n=12). Conclusion: Multiparity and elevated BMI were common risk factors across all study. This analysis underscores the necessity for early recognition, multidisciplinary management, and tailored therapeutic approaches to optimize outcomes in these complex obstetric scenarios.

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IJARIIE Roshan Shah, and Prof. Wang Zhimei . "Liver Disease in Pregnancy: A Comprehensive Clinical Analysis" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 1 2026 Page 750-761
MLA Roshan Shah, and Prof. Wang Zhimei . "Liver Disease in Pregnancy: A Comprehensive Clinical Analysis." International Journal Of Advance Research And Innovative Ideas In Education 12.1(2026) : 750-761.
APA Roshan Shah, & Prof. Wang Zhimei . (2026). Liver Disease in Pregnancy: A Comprehensive Clinical Analysis. International Journal Of Advance Research And Innovative Ideas In Education, 12(1), 750-761.
Chicago Roshan Shah, and Prof. Wang Zhimei . "Liver Disease in Pregnancy: A Comprehensive Clinical Analysis." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 1 (2026) : 750-761.
Oxford Roshan Shah, and Prof. Wang Zhimei . 'Liver Disease in Pregnancy: A Comprehensive Clinical Analysis', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, 2026, p. 750-761. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Liver_Disease_in_Pregnancy__A_Comprehensive_Clinical_Analysis_ijariie28025.pdf (Accessed : ).
Harvard Roshan Shah, and Prof. Wang Zhimei . (2026) 'Liver Disease in Pregnancy: A Comprehensive Clinical Analysis', International Journal Of Advance Research And Innovative Ideas In Education, 12(1), pp. 750-761IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Liver_Disease_in_Pregnancy__A_Comprehensive_Clinical_Analysis_ijariie28025.pdf (Accessed : )
IEEE Roshan Shah, and Prof. Wang Zhimei , "Liver Disease in Pregnancy: A Comprehensive Clinical Analysis," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, pp. 750-761, Jan-Feb 2026. [Online]. Available: https://ijariie.com/AdminUploadPdf/Liver_Disease_in_Pregnancy__A_Comprehensive_Clinical_Analysis_ijariie28025.pdf [Accessed : ].
Turabian Roshan Shah, and Prof. Wang Zhimei . "Liver Disease in Pregnancy: A Comprehensive Clinical Analysis." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 1 ().
Vancouver Roshan Shah, and Prof. Wang Zhimei . Liver Disease in Pregnancy: A Comprehensive Clinical Analysis. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : ]; 12(1) : 750-761. Available from: https://ijariie.com/AdminUploadPdf/Liver_Disease_in_Pregnancy__A_Comprehensive_Clinical_Analysis_ijariie28025.pdf
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