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Title: :  Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life
PaperId: :  28185
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 2 2026
DUI:    16.0415/IJARIIE-28185
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dhyanendra Singh YadavIPS College of Pharmacy, Gwalior
Bharat Kumar TyagiIPS College of Pharmacy, Gwalior
Sandeep JainIPS College of Pharmacy, Gwalior

Abstract

Pharmaceutical Sciences
Hydrogel, microspheres, epilepsy, levetiracetam, half life
The objective of the present investigation was to explore the hydrogel microspheres loaded with levetiracetam in order to improve the biological half-life of the drug by controlling the drug release. These hydrogel microspheres would be developed as oral delivery system for the release of levetiracetam, prolonging its release in the systemic circulation. Levetiracetam loaded hydrogel microspheres were prepared using Agarsoe/Pluronic F127 blend and emulsification method. F7 with blend ratio 3.33:1 exhibited the highest encapsulation efficiency (87.23%) whereas the lowest encapsulation was witnesses in the formulation F3 (39.93%) which has a blend ratio of 15:1. The particle size ranged from 110 µm for F3 to 277 µm for F7 and all the microspheres exhibited negative zeta potential and the values ranged from -14.2 to -18.5 mV. The SEM image exhibited irregular, frequently spherical shaped particles with non-porous and smooth surface. F3 exhibited the highest water uptake (385.5 %) whereas F7 exhibited the lowest water uptake (151.5 %). F7 released around 70.3% drug after 24 h and was considered to be the most optimized formulation. The release of Levetiracetam from F7 followed Korsemeyer-Peppas mathematical model suggesting non-Fickian diffusion.

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IJARIIE Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. "Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 2 2026 Page 649-655
MLA Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. "Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life." International Journal Of Advance Research And Innovative Ideas In Education 12.2(2026) : 649-655.
APA Dhyanendra Singh Yadav, Bharat Kumar Tyagi, & Sandeep Jain. (2026). Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life. International Journal Of Advance Research And Innovative Ideas In Education, 12(2), 649-655.
Chicago Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. "Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 2 (2026) : 649-655.
Oxford Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. 'Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 2, 2026, p. 649-655. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Formulation_and_Evaluation_of_hydrogel_microspheres_of_levetiracetam_for_improving_half_life_ijariie28185.pdf (Accessed : ).
Harvard Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. (2026) 'Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life', International Journal Of Advance Research And Innovative Ideas In Education, 12(2), pp. 649-655IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Formulation_and_Evaluation_of_hydrogel_microspheres_of_levetiracetam_for_improving_half_life_ijariie28185.pdf (Accessed : )
IEEE Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain, "Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 2, pp. 649-655, Mar-App 2026. [Online]. Available: https://ijariie.com/AdminUploadPdf/Formulation_and_Evaluation_of_hydrogel_microspheres_of_levetiracetam_for_improving_half_life_ijariie28185.pdf [Accessed : ].
Turabian Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. "Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 2 ().
Vancouver Dhyanendra Singh Yadav, Bharat Kumar Tyagi, and Sandeep Jain. Formulation and Evaluation of hydrogel microspheres of levetiracetam for improving half life. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : ]; 12(2) : 649-655. Available from: https://ijariie.com/AdminUploadPdf/Formulation_and_Evaluation_of_hydrogel_microspheres_of_levetiracetam_for_improving_half_life_ijariie28185.pdf
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