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Title: :  Understanding Alzheimer’s disease: A Review
PaperId: :  2100
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 2 Issue 3 2016
DUI:    16.0415/IJARIIE-2100
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Pankaj VermaP. D. Memorial College of Pharmacy, Bahadurgarh, India

Abstract

Biological and Medical Science (Pharmacy, Pharmacology & Therapeutics)
Alzheimer Disease; Total Tau; Phosphorylated Tau; Amyloid Beta
Alzheimer Disease is a neurodegenerative disease characterized by cognitive decline leading to complete need for care within several years after clinical diagnosis. Alzheimer disease is characterized by deposition of amyloid plaques affecting memory, behaviour as well as cognition. Alzheimer’s disease (AD) was discovered more than a hundred years ago. In spite all of this, the etiology and pathogenesis of the disease, as well as the occurence of the primary changes in the brain are still not fully understood. Pathophysiology changes due to AD involves loss of neurons, deposition of amyloid plaques, Neurofibrillary tangles, neurotransmitter changes such as cholinergic depletion, GABA, somatostatin, glutamate and corticotropin. Total Tau, Amyloid beta and phosphorylated Tau are the main biomarkers which act as a prospective tool in unfolding mysteries regarding mechanism as well as preventive measures towards occurrence of dementia. Certain animal models are also utilized for clinical studies of various anti-alzheimer drugs. Despite of pharmacological and non-pharmacological treatment, special care is needed to the patient. The main focus in AD research lies between underlying risk factors as well as newer therapies or treatment for delaying and preventing symptoms and onset of AD.

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IJARIIE Pankaj Verma. "Understanding Alzheimer’s disease: A Review" International Journal Of Advance Research And Innovative Ideas In Education Volume 2 Issue 3 2016 Page 3315-3327
MLA Pankaj Verma. "Understanding Alzheimer’s disease: A Review." International Journal Of Advance Research And Innovative Ideas In Education 2.3(2016) : 3315-3327.
APA Pankaj Verma. (2016). Understanding Alzheimer’s disease: A Review. International Journal Of Advance Research And Innovative Ideas In Education, 2(3), 3315-3327.
Chicago Pankaj Verma. "Understanding Alzheimer’s disease: A Review." International Journal Of Advance Research And Innovative Ideas In Education 2, no. 3 (2016) : 3315-3327.
Oxford Pankaj Verma. 'Understanding Alzheimer’s disease: A Review', International Journal Of Advance Research And Innovative Ideas In Education, vol. 2, no. 3, 2016, p. 3315-3327. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Understanding_Alzheimer’s_disease__A_Review_ijariie2100.pdf (Accessed : 25 August 2018).
Harvard Pankaj Verma. (2016) 'Understanding Alzheimer’s disease: A Review', International Journal Of Advance Research And Innovative Ideas In Education, 2(3), pp. 3315-3327IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Understanding_Alzheimer’s_disease__A_Review_ijariie2100.pdf (Accessed : 25 August 2018)
IEEE Pankaj Verma, "Understanding Alzheimer’s disease: A Review," International Journal Of Advance Research And Innovative Ideas In Education, vol. 2, no. 3, pp. 3315-3327, May-Jun 2016. [Online]. Available: https://ijariie.com/AdminUploadPdf/Understanding_Alzheimer’s_disease__A_Review_ijariie2100.pdf [Accessed : 25 August 2018].
Turabian Pankaj Verma. "Understanding Alzheimer’s disease: A Review." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 2 number 3 (25 August 2018).
Vancouver Pankaj Verma. Understanding Alzheimer’s disease: A Review. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2016 [Cited : 25 August 2018]; 2(3) : 3315-3327. Available from: https://ijariie.com/AdminUploadPdf/Understanding_Alzheimer’s_disease__A_Review_ijariie2100.pdf
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