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Title: :  OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY
PaperId: :  12464
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 4 2020
DUI:    16.0415/IJARIIE-12464
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
H.P. JAYADEVAPPA,Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru, India

Abstract

CHEMICAL SCIENCE
Trimetazidine, N-bromo succinamide, stoichiometry, oxidation, rate law
The kinetics of oxidation of Trimetazidine by N-bromo succinamide in perchloric acid medium has been studied at 303K. The products of oxidation were tested and stoichiometry of reaction was determined. The rate of reaction was observed to show a first order dependence on oxidant, fractional order on substrate and inverse fractional order on [H+]. The dielectric constant has a slight negative effect. The unchanged rate with ionic strength indicate involvement of non ionic species in rate determining step. The kinetic runs were performed at different temperature and thermodynamic parameters were computed. A mechanism consistent with observed parameters is proposed. Rate law is derived.

Citations

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IJARIIE H.P. JAYADEVAPPA,. "OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 4 2020 Page 1412-1418
MLA H.P. JAYADEVAPPA,. "OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY." International Journal Of Advance Research And Innovative Ideas In Education 6.4(2020) : 1412-1418.
APA H.P. JAYADEVAPPA,. (2020). OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY. International Journal Of Advance Research And Innovative Ideas In Education, 6(4), 1412-1418.
Chicago H.P. JAYADEVAPPA,. "OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 4 (2020) : 1412-1418.
Oxford H.P. JAYADEVAPPA,. 'OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, 2020, p. 1412-1418. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/OXIDATION_OF_THE_DRUG_TRIMETAZIDINE_BY_N_BROMOSUCCINIMIDE__IN_AQUEOUS_MEDIUM_–_A_KINETIC_STUDY_ijariie12464.pdf (Accessed : 10 August 2020).
Harvard H.P. JAYADEVAPPA,. (2020) 'OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY', International Journal Of Advance Research And Innovative Ideas In Education, 6(4), pp. 1412-1418IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/OXIDATION_OF_THE_DRUG_TRIMETAZIDINE_BY_N_BROMOSUCCINIMIDE__IN_AQUEOUS_MEDIUM_–_A_KINETIC_STUDY_ijariie12464.pdf (Accessed : 10 August 2020)
IEEE H.P. JAYADEVAPPA,, "OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, pp. 1412-1418, Jul-Aug 2020. [Online]. Available: http://ijariie.com/AdminUploadPdf/OXIDATION_OF_THE_DRUG_TRIMETAZIDINE_BY_N_BROMOSUCCINIMIDE__IN_AQUEOUS_MEDIUM_–_A_KINETIC_STUDY_ijariie12464.pdf [Accessed : 10 August 2020].
Turabian H.P. JAYADEVAPPA,. "OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 4 (10 August 2020).
Vancouver H.P. JAYADEVAPPA,. OXIDATION OF THE DRUG TRIMETAZIDINE BY N-BROMOSUCCINIMIDE IN AQUEOUS MEDIUM – A KINETIC STUDY. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : 10 August 2020]; 6(4) : 1412-1418. Available from: http://ijariie.com/AdminUploadPdf/OXIDATION_OF_THE_DRUG_TRIMETAZIDINE_BY_N_BROMOSUCCINIMIDE__IN_AQUEOUS_MEDIUM_–_A_KINETIC_STUDY_ijariie12464.pdf
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