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Title: :  Role of Glycomimetics in treatment of malaria
PaperId: :  12490
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 6 Issue 4 2020
DUI:    16.0415/IJARIIE-12490
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Sumeet GuptaIndependent Researcher, BDS, Chandigarh India
Swati GuptaIndependent Researcher, MDS, Chandigarh India
Richa GuptaAssistant Professor, PGIMER , Chandigarh. India
Minoti GuptaIndependent Researcher, M.Sc Hons Biophysics, Chandigarh India

Abstract

Bioinformatics
Malaria invasion, plasmodium invasion, merozoite invasion, invasion inhibitor
Background:Increased resistance to anti-malarial drugs has caused a havoc, tolling many lives It has become an imminent need of hour is to find therapeutics drugs with novel mechanism of action. In the present study,we intended to study the invasion inhibitory potential of drugs belonging to the class of Glycomimetics. Methodology: Molecular docking study was performed with eight drug molecules. 3-dimensional chemical structures of molecules were prepared through UCSF Chimera and Autodock Tools freeware.Further, Molecular docking study was performed using AutoDockVina ,Discovery studio 4.5 was used to predict the active site of target sites and PyMol to visualise the induced fit docking. Results: The preliminary experimental study demonstrated that Acarbose and Hyaluronic acid show good binding efficacy to all the target proteins of Plasmodium species. On the basis of molecular docking studies it can be suggested that Acarbose and Hyaluronic acid are potential inhibitors of merozoite invasion into erythrocytes. However, further in-vitro and in-vivo studies needs to be performed for further drug development process.

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IJARIIE Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. "Role of Glycomimetics in treatment of malaria" International Journal Of Advance Research And Innovative Ideas In Education Volume 6 Issue 4 2020 Page 1470-1479
MLA Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. "Role of Glycomimetics in treatment of malaria." International Journal Of Advance Research And Innovative Ideas In Education 6.4(2020) : 1470-1479.
APA Sumeet Gupta, Swati Gupta, Richa Gupta, & Minoti Gupta. (2020). Role of Glycomimetics in treatment of malaria. International Journal Of Advance Research And Innovative Ideas In Education, 6(4), 1470-1479.
Chicago Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. "Role of Glycomimetics in treatment of malaria." International Journal Of Advance Research And Innovative Ideas In Education 6, no. 4 (2020) : 1470-1479.
Oxford Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. 'Role of Glycomimetics in treatment of malaria', International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, 2020, p. 1470-1479. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Role_of_Glycomimetics_in_treatment_of_malaria_ijariie12490.pdf (Accessed : ).
Harvard Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. (2020) 'Role of Glycomimetics in treatment of malaria', International Journal Of Advance Research And Innovative Ideas In Education, 6(4), pp. 1470-1479IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Role_of_Glycomimetics_in_treatment_of_malaria_ijariie12490.pdf (Accessed : )
IEEE Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta, "Role of Glycomimetics in treatment of malaria," International Journal Of Advance Research And Innovative Ideas In Education, vol. 6, no. 4, pp. 1470-1479, Jul-Aug 2020. [Online]. Available: http://ijariie.com/AdminUploadPdf/Role_of_Glycomimetics_in_treatment_of_malaria_ijariie12490.pdf [Accessed : ].
Turabian Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. "Role of Glycomimetics in treatment of malaria." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 6 number 4 ().
Vancouver Sumeet Gupta, Swati Gupta, Richa Gupta, and Minoti Gupta. Role of Glycomimetics in treatment of malaria. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2020 [Cited : ]; 6(4) : 1470-1479. Available from: http://ijariie.com/AdminUploadPdf/Role_of_Glycomimetics_in_treatment_of_malaria_ijariie12490.pdf
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