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Call for Papers:Vol.11 Issue.3

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Title: :  Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance
PaperId: :  26451
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 11 Issue 3 2025
DUI:    16.0415/IJARIIE-26451
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Mr.Gaurav Shirsath Shivajirao Pawar College of Pharmacy
Prof. Ashwini WakadeShivajirao Pawar College of Pharmacy
Dr.Megha Salve Shivajirao Pawar College of Pharmacy

Abstract

Pharmacy
Famciclovir, Oral Mucosal Tablet, Mucoadhesive Drug Delivery, Fast Dissolving Tablets, Antiviral Therapy, Buccal Absorption, In-vitro Evaluation, Carbopol, HPMC, Bioavailability Enhancement
Abstract - The present research focuses on the formulation and evaluation of Famciclovir 500 mg oral mucosal tablets intended for the effective and patient-friendly treatment of viral infections such as herpes zoster and herpes simplex. Famciclovir, a prodrug of penciclovir, suffers from limited oral bioavailability due to hepatic first-pass metabolism. To overcome this limitation and improve therapeutic efficacy, an oral mucosal tablet was designed to allow direct absorption through the oral mucosa, thereby bypassing hepatic metabolism.The formulation process employed a combination of mucoadhesive and disintegration-promoting excipients. Hydroxypropyl Methylcellulose (HPMC) and Carbopol 974P were selected for their excellent mucoadhesive properties, while Croscarmellose Sodium served as a superdisintegrant to ensure rapid tablet disintegration. Additional ingredients such as Polysorbate 80 and Sodium Lauryl Sulfate were incorporated to enhance solubility and drug dispersion. Polyvinylpyrrolidone (PVP) K30 was used as a binder, and patient acceptability was increased with the addition of aspartame and peppermint flavor. Microcrystalline Cellulose was employed as a diluent to achieve the desired tablet weight and compressibility.

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IJARIIE Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance" International Journal Of Advance Research And Innovative Ideas In Education Volume 11 Issue 3 2025 Page 342-354
MLA Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance." International Journal Of Advance Research And Innovative Ideas In Education 11.3(2025) : 342-354.
APA Mr.Gaurav Shirsath , Prof. Ashwini Wakade, & Dr.Megha Salve . (2025). Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance. International Journal Of Advance Research And Innovative Ideas In Education, 11(3), 342-354.
Chicago Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance." International Journal Of Advance Research And Innovative Ideas In Education 11, no. 3 (2025) : 342-354.
Oxford Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . 'Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance', International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 3, 2025, p. 342-354. Available from IJARIIE, http://ijariie.com/AdminUploadPdf/Development__Optimization__and_In_Vitro_Evaluation_of_Mucoadhesive_Famciclovir_500_mg_Oral_Mucosal_Tablets_for_Enhanced_Bioavailability_and_Improved_Patient_Compliance_ijariie26451.pdf (Accessed : ).
Harvard Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . (2025) 'Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance', International Journal Of Advance Research And Innovative Ideas In Education, 11(3), pp. 342-354IJARIIE [Online]. Available at: http://ijariie.com/AdminUploadPdf/Development__Optimization__and_In_Vitro_Evaluation_of_Mucoadhesive_Famciclovir_500_mg_Oral_Mucosal_Tablets_for_Enhanced_Bioavailability_and_Improved_Patient_Compliance_ijariie26451.pdf (Accessed : )
IEEE Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve , "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance," International Journal Of Advance Research And Innovative Ideas In Education, vol. 11, no. 3, pp. 342-354, May-Jun 2025. [Online]. Available: http://ijariie.com/AdminUploadPdf/Development__Optimization__and_In_Vitro_Evaluation_of_Mucoadhesive_Famciclovir_500_mg_Oral_Mucosal_Tablets_for_Enhanced_Bioavailability_and_Improved_Patient_Compliance_ijariie26451.pdf [Accessed : ].
Turabian Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . "Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 11 number 3 ().
Vancouver Mr.Gaurav Shirsath , Prof. Ashwini Wakade, and Dr.Megha Salve . Development, Optimization, and In-Vitro Evaluation of Mucoadhesive Famciclovir 500 mg Oral Mucosal Tablets for Enhanced Bioavailability and Improved Patient Compliance. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2025 [Cited : ]; 11(3) : 342-354. Available from: http://ijariie.com/AdminUploadPdf/Development__Optimization__and_In_Vitro_Evaluation_of_Mucoadhesive_Famciclovir_500_mg_Oral_Mucosal_Tablets_for_Enhanced_Bioavailability_and_Improved_Patient_Compliance_ijariie26451.pdf
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