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Title: :  In-silico studies on phytochemical, Carpaine in papaya leaves
PaperId: :  21419
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 4 2023
DUI:    16.0415/IJARIIE-21419
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Dr Heena V Sanghani Vivekanand College Kolhapur, Maharashtra, India
Dr Sunita D ShirkeVivekanand College Kolhapur, Maharashtra, India
Ms. Pratiksha U KurneVivekanand College Kolhapur, Maharashtra, India

Abstract

Applied Chemistry
Phytochemical, Carica papaya leaves, anti-cancer, Ligand, protein interactions, Carpaine, binding affinity, structure-based drug design
Cyclin dependent kinases are critical molecules that control cell cycle progression from one phase to the other. In humans, mutations in cyclin dependent kinase 2 (1GII) is responsible for nearly 50% of cancers. This study evaluates in-vitro and in-silico study of a phytochemical carpaine obtained from Carica papaya leaves.. Computational docking was used to predict conformations and free binding energy for ligand carpaine with CDK4 protein 1GII. In silico studies were done on different conformers of ligand carpaine and receptor 1GII, a CDK4 protein which gives binding free energy of -7.44 Kcal/ mole. This study reveals the pharmacokinetic properties and Lipinski’s rule of five. Two hydrogen bonds were also obtained between them. Docking results for carpaine may be promising towards it as anticancer drug candidate.

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IJARIIE Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. "In-silico studies on phytochemical, Carpaine in papaya leaves" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 4 2023 Page 2879-2885
MLA Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. "In-silico studies on phytochemical, Carpaine in papaya leaves." International Journal Of Advance Research And Innovative Ideas In Education 9.4(2023) : 2879-2885.
APA Dr Heena V Sanghani , Dr Sunita D Shirke, & Ms. Pratiksha U Kurne. (2023). In-silico studies on phytochemical, Carpaine in papaya leaves. International Journal Of Advance Research And Innovative Ideas In Education, 9(4), 2879-2885.
Chicago Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. "In-silico studies on phytochemical, Carpaine in papaya leaves." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 4 (2023) : 2879-2885.
Oxford Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. 'In-silico studies on phytochemical, Carpaine in papaya leaves', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 4, 2023, p. 2879-2885. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/In_silico_studies_on_phytochemical__Carpaine_in_papaya_leaves_ijariie21419.pdf (Accessed : ).
Harvard Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. (2023) 'In-silico studies on phytochemical, Carpaine in papaya leaves', International Journal Of Advance Research And Innovative Ideas In Education, 9(4), pp. 2879-2885IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/In_silico_studies_on_phytochemical__Carpaine_in_papaya_leaves_ijariie21419.pdf (Accessed : )
IEEE Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne, "In-silico studies on phytochemical, Carpaine in papaya leaves," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 4, pp. 2879-2885, Jul-Aug 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/In_silico_studies_on_phytochemical__Carpaine_in_papaya_leaves_ijariie21419.pdf [Accessed : ].
Turabian Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. "In-silico studies on phytochemical, Carpaine in papaya leaves." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 4 ().
Vancouver Dr Heena V Sanghani , Dr Sunita D Shirke, and Ms. Pratiksha U Kurne. In-silico studies on phytochemical, Carpaine in papaya leaves. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : ]; 9(4) : 2879-2885. Available from: https://ijariie.com/AdminUploadPdf/In_silico_studies_on_phytochemical__Carpaine_in_papaya_leaves_ijariie21419.pdf
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