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Title: :  A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES
PaperId: :  21532
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 9 Issue 5 2023
DUI:    16.0415/IJARIIE-21532
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Neha PatelSSSUTMS
Dr. Syed Shahab Ahmed SSSUTMS

Abstract

SCIENCE
Vitamin D deficiency, Muscle wasting, Adiposity changes, Biochemical mechanisms, Interplay
Vitamin D is a fat-soluble secosteroid hormone essential for maintaining various physiological processes, including bone health, immune function, and cellular metabolism. Emerging research has illuminated the intricate biochemical and molecular mechanisms underlying the association between vitamin D deficiency and muscle wasting, as well as adiposity changes. This abstract provides an overview of these mechanisms, shedding light on the multifaceted relationship between vitamin D status and musculoskeletal health. Muscle wasting, characterized by the loss of muscle mass and function, is a common consequence of vitamin D deficiency. Vitamin D plays a crucial role in skeletal muscle development, maintenance, and repair through its interaction with the vitamin D receptor (VDR) present in muscle tissue. The active form of vitamin D, calcitriol, binds to VDR, initiating genomic and non-genomic pathways that influence muscle protein synthesis, mitochondrial function, and muscle fiber composition. In vitamin D deficiency, these processes are compromised, leading to muscle atrophy and weakness. Furthermore, vitamin D deficiency has been linked to adiposity changes, specifically an increase in visceral adipose tissue. Adipose tissue expresses VDR, and the active form of vitamin D regulates adipogenesis and adipokine secretion. Insufficient vitamin D levels disrupt these regulatory mechanisms, promoting the expansion of visceral fat and the release of pro-inflammatory cytokines. This adiposity change contributes to a pro-inflammatory state and insulin resistance, increasing the risk of metabolic disorders such as obesity and type 2 diabetes.

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IJARIIE Neha Patel, and Dr. Syed Shahab Ahmed . "A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES" International Journal Of Advance Research And Innovative Ideas In Education Volume 9 Issue 5 2023 Page 100-107
MLA Neha Patel, and Dr. Syed Shahab Ahmed . "A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES." International Journal Of Advance Research And Innovative Ideas In Education 9.5(2023) : 100-107.
APA Neha Patel, & Dr. Syed Shahab Ahmed . (2023). A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES. International Journal Of Advance Research And Innovative Ideas In Education, 9(5), 100-107.
Chicago Neha Patel, and Dr. Syed Shahab Ahmed . "A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES." International Journal Of Advance Research And Innovative Ideas In Education 9, no. 5 (2023) : 100-107.
Oxford Neha Patel, and Dr. Syed Shahab Ahmed . 'A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES', International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, 2023, p. 100-107. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/A_COMPREHENSIVE_REVIEW_OF_BIO_CHEMICAL_AND_MOLECULAR_MECHANISM_OF_VITAMIN_D_DEFICIENCY_INCLUDES_MUSCLE_WASTING_AND_ADIPOSITY_CHANGES_ijariie21532.pdf (Accessed : 11 September 2023).
Harvard Neha Patel, and Dr. Syed Shahab Ahmed . (2023) 'A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES', International Journal Of Advance Research And Innovative Ideas In Education, 9(5), pp. 100-107IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/A_COMPREHENSIVE_REVIEW_OF_BIO_CHEMICAL_AND_MOLECULAR_MECHANISM_OF_VITAMIN_D_DEFICIENCY_INCLUDES_MUSCLE_WASTING_AND_ADIPOSITY_CHANGES_ijariie21532.pdf (Accessed : 11 September 2023)
IEEE Neha Patel, and Dr. Syed Shahab Ahmed , "A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES," International Journal Of Advance Research And Innovative Ideas In Education, vol. 9, no. 5, pp. 100-107, Sep-Oct 2023. [Online]. Available: https://ijariie.com/AdminUploadPdf/A_COMPREHENSIVE_REVIEW_OF_BIO_CHEMICAL_AND_MOLECULAR_MECHANISM_OF_VITAMIN_D_DEFICIENCY_INCLUDES_MUSCLE_WASTING_AND_ADIPOSITY_CHANGES_ijariie21532.pdf [Accessed : 11 September 2023].
Turabian Neha Patel, and Dr. Syed Shahab Ahmed . "A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 9 number 5 (11 September 2023).
Vancouver Neha Patel, and Dr. Syed Shahab Ahmed . A COMPREHENSIVE REVIEW OF BIO CHEMICAL AND MOLECULAR MECHANISM OF VITAMIN D DEFICIENCY INCLUDES MUSCLE WASTING AND ADIPOSITY CHANGES. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2023 [Cited : 11 September 2023]; 9(5) : 100-107. Available from: https://ijariie.com/AdminUploadPdf/A_COMPREHENSIVE_REVIEW_OF_BIO_CHEMICAL_AND_MOLECULAR_MECHANISM_OF_VITAMIN_D_DEFICIENCY_INCLUDES_MUSCLE_WASTING_AND_ADIPOSITY_CHANGES_ijariie21532.pdf
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