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Title: :  Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation
PaperId: :  27937
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 1 2026
DUI:    16.0415/IJARIIE-27937
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
ATAZHANOV SARDORBEK MDDepartment of oral and maxillofacial surgery First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China 
NAJEEB ULLAH PhDDepartment of Endocrinology First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China  Email: Najeebzarger@gmail.com
MAMATURSIN TURDI* {Corresponding Author }Department of oral and maxillofacial surgery First Affiliated Hospital of Xinjiang Medical University,Ürümqi,Xinjiang,China 

Abstract

Medicine/Surgery
Platelet-Rich Fibrin; Bone Regeneration; Tissue Engineering; Growth Factors; Molecular Mechanisms; Clinical Translation; Standardization.
Platelet-rich fibrin (PRF), a second-generation autologous platelet concentrate, represents a paradigm shift in regenerative biomaterials. Distinguished by its three-dimensional fibrin matrix, PRF orchestrates a sustained, sequential release of growth factors and cytokines, establishing a biomimetic osteogenic niche [1, 2]. This review systematically deconstructs the preparation-property-function relationship of PRF and its derivatives (L-PRF, A-PRF, i-PRF, T-PRF), linking centrifugal parameters to quantifiable scaffold architecture and release kinetics [3, 4]. A central thesis posits that PRF's efficacy stems from a tripartite mechanism: direct osteogenic programming of progenitor cells via BMP/Smad and MAPK/ERK pathways [5, 6]; potentiation of mature osteoblast function and matrix mineralization [7]; and strategic remodeling of the healing microenvironment through coupled angiogenesis and immunomodulation [8, 9]. Evidence-based clinical appraisal confirms its utility in oral and maxillofacial surgery, with data indicating a 35-50% enhancement in bone density and healing rates in procedures such as sinus augmentation and alveolar ridge preservation [10, 11]. However, clinical translation is impeded by protocol heterogeneity and suboptimal degradation kinetics [12]. We conclude by proposing a roadmap integrating engineered PRF composites with tunable properties and AI-optimized preparation protocols to transition PRF from a biological tool to a standardized, next-generation therapeutic platform [13, 14].

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IJARIIE ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. "Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 1 2026 Page 158-169
MLA ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. "Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation." International Journal Of Advance Research And Innovative Ideas In Education 12.1(2026) : 158-169.
APA ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, & MAMATURSIN TURDI* {Corresponding Author }. (2026). Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation. International Journal Of Advance Research And Innovative Ideas In Education, 12(1), 158-169.
Chicago ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. "Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 1 (2026) : 158-169.
Oxford ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. 'Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, 2026, p. 158-169. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Platelet_Rich_Fibrin_in_Bone_Regeneration__A_Systems_Biology_Approach_to_Mechanisms_and_Clinical_Translation_ijariie27937.pdf (Accessed : ).
Harvard ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. (2026) 'Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation', International Journal Of Advance Research And Innovative Ideas In Education, 12(1), pp. 158-169IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Platelet_Rich_Fibrin_in_Bone_Regeneration__A_Systems_Biology_Approach_to_Mechanisms_and_Clinical_Translation_ijariie27937.pdf (Accessed : )
IEEE ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }, "Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, pp. 158-169, Jan-Feb 2026. [Online]. Available: https://ijariie.com/AdminUploadPdf/Platelet_Rich_Fibrin_in_Bone_Regeneration__A_Systems_Biology_Approach_to_Mechanisms_and_Clinical_Translation_ijariie27937.pdf [Accessed : ].
Turabian ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. "Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 1 ().
Vancouver ATAZHANOV SARDORBEK MD, NAJEEB ULLAH PhD, and MAMATURSIN TURDI* {Corresponding Author }. Platelet-Rich Fibrin in Bone Regeneration: A Systems Biology Approach to Mechanisms and Clinical Translation. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : ]; 12(1) : 158-169. Available from: https://ijariie.com/AdminUploadPdf/Platelet_Rich_Fibrin_in_Bone_Regeneration__A_Systems_Biology_Approach_to_Mechanisms_and_Clinical_Translation_ijariie27937.pdf
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