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Title: :  ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW
PaperId: :  28007
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 12 Issue 1 2026
DUI:    16.0415/IJARIIE-28007
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Snehal JadhavAssistant Professor, Department of Chemistry, Vishwasrao Ransing College, Kalamb ,Walchandnagar, Pune, India-413114
Prajakta SonawaneAssistant Professor, Department of Chemistry, Vishwasrao Ransing College, Kalamb ,Walchandnagar, Pune, India-413114
Akanksha MetakariAssistant Professor, Department of Chemistry, Vishwasrao Ransing College, Kalamb ,Walchandnagar, Pune, India-413114
Priyanka ChavhanAssistant Professor, Department of Chemistry, Vishwasrao Ransing College, Kalamb ,Walchandnagar, Pune, India-413114

Abstract

Pharmaceutical Chemistry
Chlorpheniramine Maleate, analytical methods, HPLC
Background: Chlorpheniramine Maleate is a first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticarial. Chlorpheniramine maleate was FDA approved in the united state as a prescription-only productin 1948, and laterin 2010, it got approval as an over-the-counter medication. Design, synthesis of chlorpheniramine maleate has one asymmetric carbon atom,exists as racemic mixture of R and S forms and does not show optical rotation. It is a histamine H1 receptor ant agonist used as an anti-histamine. Method: Various analytical techniques for the quantification of chlorpheniramine maleate for bulk, pharmaceutical formulations and biological samples have been reported. Assay methods include UV-spectroscopy, high performance liquid chromatography, high performance thin layer chromatography. Result: Literature review reveals that methanol is the most commonly used solvent for the analysis of chlorpheniramine maleate by spectroscopic technique. For estimation of chlorpheniramine maleate by high performance liquid chromatography, methanol and acetonitrile are the commonly used organic solvents in the mobile phase and phosphate buffer or triuroacetic acid is used to maintain the pH of the mobile phase. Protein precipitation technique is used widely for extraction of the chlorpheniramine maleate from biological samples though liquid-liquid extraction and solid phase extraction has also been reported in fewer articles. The electroanalytical techniques reported for the analysis of the drug have provided methods with lower analysis time. Conclusion: Amongst all the developed analytical methods, HPLC has been reported extensively for the quantitation for chlorpheniramine maleate.

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IJARIIE Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. "ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW" International Journal Of Advance Research And Innovative Ideas In Education Volume 12 Issue 1 2026 Page 699-707
MLA Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. "ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW." International Journal Of Advance Research And Innovative Ideas In Education 12.1(2026) : 699-707.
APA Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, & Priyanka Chavhan. (2026). ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW. International Journal Of Advance Research And Innovative Ideas In Education, 12(1), 699-707.
Chicago Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. "ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW." International Journal Of Advance Research And Innovative Ideas In Education 12, no. 1 (2026) : 699-707.
Oxford Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. 'ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW', International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, 2026, p. 699-707. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/ANALYTICAL_METHODS_FOR_QUANTITATIVE_ESTIMATION_OF_CHLORPHENIRAMINE_MALEATE__A_REVIEW_ijariie28007.pdf (Accessed : 06 March 2026).
Harvard Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. (2026) 'ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW', International Journal Of Advance Research And Innovative Ideas In Education, 12(1), pp. 699-707IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/ANALYTICAL_METHODS_FOR_QUANTITATIVE_ESTIMATION_OF_CHLORPHENIRAMINE_MALEATE__A_REVIEW_ijariie28007.pdf (Accessed : 06 March 2026)
IEEE Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan, "ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW," International Journal Of Advance Research And Innovative Ideas In Education, vol. 12, no. 1, pp. 699-707, Jan-Feb 2026. [Online]. Available: https://ijariie.com/AdminUploadPdf/ANALYTICAL_METHODS_FOR_QUANTITATIVE_ESTIMATION_OF_CHLORPHENIRAMINE_MALEATE__A_REVIEW_ijariie28007.pdf [Accessed : 06 March 2026].
Turabian Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. "ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 12 number 1 (06 March 2026).
Vancouver Snehal Jadhav, Prajakta Sonawane, Akanksha Metakari, and Priyanka Chavhan. ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF CHLORPHENIRAMINE MALEATE: A REVIEW. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2026 [Cited : 06 March 2026]; 12(1) : 699-707. Available from: https://ijariie.com/AdminUploadPdf/ANALYTICAL_METHODS_FOR_QUANTITATIVE_ESTIMATION_OF_CHLORPHENIRAMINE_MALEATE__A_REVIEW_ijariie28007.pdf
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