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Title: :  NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM
PaperId: :  22528
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 1 2024
DUI:    16.0415/IJARIIE-22528
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
K.PramodVenkateshwara institute of Pharmaceutical Sciences, Cherlapally, Nalgonda
M.MamathaVenkateshwara institute of Pharmaceutical Sciences, Cherlapally, Nalgonda
N .Ranjith kumarVenkateshwara institute of Pharmaceutical Sciences, Cherlapally, Nalgonda
M.Rajavardhan reddyVenkateshwara institute of Pharmaceutical Sciences, Cherlapally, Nalgonda

Abstract

pharmacy
Iguratimod, validation, development, stability indicating methodology.
The present study describes a simple and stability-indicating reverse phase high-performance liquid chromatography (RP- HPLC) method for the quantification of the related substances of Iguratimod drug substance. Successful separations of the possible impurities were achieved on a Inertsil ODS-3 (150 × 4.6 mm, 5μm) and UV detector at 257nm, 0.8mL/min as a flow rate, and 20μL as an injection volume. For mobile phase-A preparation, 5.44gm potassium dihydrogen orthophosphate dissolved in 2 liter water and adjusted pH 4.00±0.05 with dilute orthophosphoric acid and filter through 0.45µ membrane filter. Use HPLC grade Acetonitrile as mobile phase- B. Use gradient flow program with column temperature 40°C. Percentage recovery obtained in the range of 80-120% and the method is linear for all possible impurities and Iguratimod for specified concentration range with coefficient of variation (r) not less than 0.99. Acid, base, peroxide and thermal degradation were carried in drug substance. The proposed RP- HPLC method was found to be specific, linear, precise, accurate and robust.

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IJARIIE K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. "NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM" International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 1 2024 Page 823-829
MLA K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. "NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education 10.1(2024) : 823-829.
APA K.Pramod, M.Mamatha, N .Ranjith kumar, & M.Rajavardhan reddy. (2024). NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM. International Journal Of Advance Research And Innovative Ideas In Education, 10(1), 823-829.
Chicago K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. "NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 1 (2024) : 823-829.
Oxford K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. 'NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 1, 2024, p. 823-829. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/NEW_METHOD_DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_FOR_THE_ESTIMATION_OF_IGURATIMOD_IN_THE_TABLET_DOSAGE__FORM_ijariie22528.pdf (Accessed : 13 March 2025).
Harvard K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. (2024) 'NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM', International Journal Of Advance Research And Innovative Ideas In Education, 10(1), pp. 823-829IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/NEW_METHOD_DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_FOR_THE_ESTIMATION_OF_IGURATIMOD_IN_THE_TABLET_DOSAGE__FORM_ijariie22528.pdf (Accessed : 13 March 2025)
IEEE K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy, "NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 1, pp. 823-829, Jan-Feb 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/NEW_METHOD_DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_FOR_THE_ESTIMATION_OF_IGURATIMOD_IN_THE_TABLET_DOSAGE__FORM_ijariie22528.pdf [Accessed : 13 March 2025].
Turabian K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. "NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 1 (13 March 2025).
Vancouver K.Pramod, M.Mamatha, N .Ranjith kumar, and M.Rajavardhan reddy. NEW METHOD DEVELOPMENT AND VALIDATION OF RP- HPLC FOR THE ESTIMATION OF IGURATIMOD IN THE TABLET DOSAGE FORM. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : 13 March 2025]; 10(1) : 823-829. Available from: https://ijariie.com/AdminUploadPdf/NEW_METHOD_DEVELOPMENT_AND_VALIDATION_OF_RP__HPLC_FOR_THE_ESTIMATION_OF_IGURATIMOD_IN_THE_TABLET_DOSAGE__FORM_ijariie22528.pdf
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