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Title: :  Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.
PaperId: :  24194
Published in:   International Journal Of Advance Research And Innovative Ideas In Education
Publisher:   IJARIIE
e-ISSN:   2395-4396
Volume/Issue:    Volume 10 Issue 3 2024
DUI:    16.0415/IJARIIE-24194
Licence: :   IJARIIE is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Author NameAuthor Institute
Shrutika Yashwant PatilNootan college of Pharmacy, Kavathe Mahankal, sangli
Shweta Ramesh NikamNootan college of Pharmacy, Kavathe Mahankal, sangli
Deepak jayappa kareNootan college of Pharmacy, Kavathe Mahankal, sangli

Abstract

Pharmacy
Flowability, Compatibility, Agglomeration, Spherical Crystallization, Direct Compression, Physicochemical properties.
In 1986, Kawashima pioneered the spherical crystallization technique for enlarging the size of drugs in the field of pharmacy. This innovative approach aimed to enhance the flow and compressibility characteristics of microcrystalline drug candidates. The process of spherical crystallization involves utilizing agglomerating solvents, quasi-emulsion solvent diffusion, and ammonia diffusion techniques. Optimization of temperature and agitation speed is crucial to achieve spherical agglomerates within the desired range, which is essential for improving compressibility. The resulting spherically agglomerated crystals can be directly prepared into tablet form or compounded into pharmaceutical systems without the need for additional processing such as granulation. Spherical crystallization serves as a particle design technique, enabling simultaneous crystallization and agglomeration in a single step. It has proven effective in enhancing the flowability and compatibility of crystalline drugs. Characterization of spherical crystals typically involves Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) to assess any physicochemical interactions between the drug and carrier that could impact dissolution. Additionally, the solubility of the crystals is evaluated to ascertain their performance.

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IJARIIE Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. "Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties." International Journal Of Advance Research And Innovative Ideas In Education Volume 10 Issue 3 2024 Page 4558-4570
MLA Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. "Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.." International Journal Of Advance Research And Innovative Ideas In Education 10.3(2024) : 4558-4570.
APA Shrutika Yashwant Patil, Shweta Ramesh Nikam, & Deepak jayappa kare. (2024). Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.. International Journal Of Advance Research And Innovative Ideas In Education, 10(3), 4558-4570.
Chicago Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. "Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.." International Journal Of Advance Research And Innovative Ideas In Education 10, no. 3 (2024) : 4558-4570.
Oxford Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. 'Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.', International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 3, 2024, p. 4558-4570. Available from IJARIIE, https://ijariie.com/AdminUploadPdf/Spherical_Crystallization_of_Depsone_To_Improve_PhysicoChemical_and_Micromeritics_Properties__ijariie24194.pdf (Accessed : ).
Harvard Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. (2024) 'Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.', International Journal Of Advance Research And Innovative Ideas In Education, 10(3), pp. 4558-4570IJARIIE [Online]. Available at: https://ijariie.com/AdminUploadPdf/Spherical_Crystallization_of_Depsone_To_Improve_PhysicoChemical_and_Micromeritics_Properties__ijariie24194.pdf (Accessed : )
IEEE Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare, "Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.," International Journal Of Advance Research And Innovative Ideas In Education, vol. 10, no. 3, pp. 4558-4570, May-Jun 2024. [Online]. Available: https://ijariie.com/AdminUploadPdf/Spherical_Crystallization_of_Depsone_To_Improve_PhysicoChemical_and_Micromeritics_Properties__ijariie24194.pdf [Accessed : ].
Turabian Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. "Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.." International Journal Of Advance Research And Innovative Ideas In Education [Online]. volume 10 number 3 ().
Vancouver Shrutika Yashwant Patil, Shweta Ramesh Nikam, and Deepak jayappa kare. Spherical Crystallization of Depsone To Improve PhysicoChemical and Micromeritics Properties.. International Journal Of Advance Research And Innovative Ideas In Education [Internet]. 2024 [Cited : ]; 10(3) : 4558-4570. Available from: https://ijariie.com/AdminUploadPdf/Spherical_Crystallization_of_Depsone_To_Improve_PhysicoChemical_and_Micromeritics_Properties__ijariie24194.pdf
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